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Incubated for more than a decade.

Paradigm-shifting research by Ireneo’s scientific co-founders has helped uncover the link between brain health and metabolic health.

Featured papers

Predicting cognitive decline

Our scientific co-founders’ foundational work showing that a lipid signature can predict dementia in people with healthy cognition.

Title - Lista et al Ageing Res Rev (2023).png
Metabolomics & dementia

A 2023 review of evidence showing that lipid metabolism is consistently altered in Alzheimer's disease.

Title - Fiandaca et al BMC Sys Biol (2017).png
Whole-person brain health

Perspective arguing why a proactive, systems healthcare approach has the most potential to reduce the burden of poor brain health.

Our work

​Lista S, González-Domínguez R, López-Ortiz S, González-Domínguez Á, Menéndez H, Martín-Hernández J, Lucia A, Emanuele E, Centonze D, Imbimbo BP, Triaca V, Lionetto L, Simmaco M, Cuperlovic-Culf M, Mill J, Li L, Mapstone M, Santos-Lozano A, Nisticò R. Integrative metabolomics science in Alzheimer's disease: Relevance and future perspectives. Ageing Res Rev. 2023 Aug;89:101987. doi: 10.1016/j.arr.2023.101987.

Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N; Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators. Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020 Apr 5;12(1):e12028. doi: 10.1002/dad2.12028.

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Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease. Dev Neurobiol. 2019 Jul;79(7):622-638. doi: 10.1002/dneu.22716.

​Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ. Potential metabolomic linkage in blood between Parkinson's disease and traumatic brain injury. Metabolites. 2018 Sep 7;8(3):50. doi: 10.3390/metabo8030050.

Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, Merchant-Borna K, Bazarian J, Federoff HJ. Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLoS One. 2018 Apr 20;13(4):e0195318. doi: 10.1371/journal.pone.0195318.

Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff HJ. What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiol Aging. 2017 Mar;51:148-155. doi: 10.1016/j.neurobiolaging.2016.11.007.

Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M, Federoff HJ. Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer's disease. Front Neurol. 2015 Nov 12;6:237. doi: 10.3389/fneur.2015.00237.

Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ. The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimers Dement. 2014 Jun;10(3 Suppl):S196-212. doi: 10.1016/j.jalz.2014.04.015.

Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014 Apr;20(4):415-8. doi: 10.1038/nm.3466.

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